Bioinformatics Mock Test 2

10%

Question 1 of 10

1. If the score is located in the extreme margin of the distribution, that means that the alignment between the two sequences is ______ due to random chance and is thus considered ______

unlikely, insignificant

unlikely, significant

very likely, significant

Question 1 of 10

Question 2 of 10

2. Which of the following is untrue about DCA?

The breaking points during the process are determined based on regional similarity of the sequences

It works by breaking each of the sequences into two smaller sections

It stands for Divide-and-Conquer Alignment

If the sections are not short enough, further divisions are restricted as well

Question 2 of 10

Question 3 of 10

3. Like other alignment programs, CLUSTAL uses a null score for opening a gap in a sequence alignment and a penalty for extending the gap by one residue.

True

False

Question 3 of 10

Question 4 of 10

4. The global sequence alignment is suitable when the two sequences are of dissimilar length, with a negligible degree of similarity throughout.

False

True

Question 4 of 10

Question 5 of 10

5. By whom and when were the Bayesian methods applied first?

Agarwal and States, 1996

Smith-Waterman, 1981

Agarwal and States, 1981

Smith-Waterman, 1996

Question 5 of 10

Question 6 of 10

6. On analysis of the alignment scores of random sequences will reveal that the scores follow a different distribution than the normal distribution called the _________

Gumbel distribution

Gumbel extreme value distribution

Gumbel end value distribution

Gumbel equal value distribution

Question 6 of 10

Question 7 of 10

7. If the selected window size is too long, sensitivity of the alignment is lost.

False

True

Question 7 of 10

Question 8 of 10

8. In a type of probability, analysis is to calculate the odds score for one event OR a second event, or of a series of events. In this case, the odds scores are _______

subtracted

added and multiplied

multiplied

added

Question 8 of 10

Question 9 of 10

9. The GCG alignment programs have a RANDOMIZATION option, which shuffles the second sequence and calculates similarity scores between the unshuffled sequence and each of the shuffled copies.

False

True

Question 9 of 10

Question 10 of 10

10. Which of the following scores are not considered while calculating the SP scores?

Number of gap penalties

All possible gap costs

All possible mismatches

All possible pair wise matches

Question 10 of 10