Bioinformatics Mock Test 4

10%

Question 1 of 10

1. Which of the following is untrue about profile method?

The propensity of amino acids in not in picture of this method

Statistical information from these aligned residues is then used to construct a profile

A profile is constructed for a group of related protein structures

The structural profile is generated by the superimposition of the structures to expose corresponding residues

Question 1 of 10

Question 2 of 10

2. Which of the following is untrue regarding Coils?

It compares the sequence to a probability matrix compiled from known parallel two-stranded coiled coils

It scans a window of fourteen, twenty-one, or twenty-eight residues

It is a web-based program that detects coiled coil regions in proteins

It scans a window of fourteen or twenty-one residues only

Question 2 of 10

Question 3 of 10

3. Which of the following is untrue regarding Homology-Based Methods?

This type of method combines the ab initio secondary structure prediction of individual sequences and alignment information from multiple homologous sequences (>35% identity)

The third generation of algorithms was developed in the late 1990s

This type of method uses the ab initio secondary structure prediction of individual sequences only

They were developed by making use of evolutionary information

Question 3 of 10

Question 4 of 10

4. Which of the following is untrue regarding Prediction of Helical Membrane Proteins?

The α-helices generally run parallel to the membrane plane

The α-helices have an average length between seventeen and twenty-five residues

For membrane proteins consisting of transmembrane α–helices, these transmembrane helices are predominantly hydrophobic with a specific distribution of positively charged residues

The α-helices generally run perpendicular to the membrane plane

Question 4 of 10

Question 5 of 10

5. In Side Chain Refinement step, A side chain can be built by searching every possible conformation at every torsion angle of the side chain to select the one that has the lowest interaction energy with neighboring atoms.

True

False

Question 5 of 10

Question 6 of 10

6. Prof is not similar to PHD.

False

True

Question 6 of 10

Question 7 of 10

7. In Rosetta, The segments with assigned _______ structures are subsequently assembled into a ______ dimensional configuration.

primary, three

secondary, three

secondary, two

Question 7 of 10

Question 8 of 10

8. Which of the following is untrue about Sequence Alignment Step?

The realignment is the most critical step in homology modeling

Errors made in the alignment step can be corrected in the following modeling steps

The realignment directly affects the quality of the final model

Once the structure with the highest sequence similarity is identified as a template, the full-length sequences of the template and target proteins need to be realigned using refined alignment algorithms to obtain optimal alignment

Question 8 of 10

Question 9 of 10

9. Which of the following is true about Gen Threader?

The initial step is quite dissimilar to 3D-PSSM

It is a web-based program that uses pairwise energy methods only

It is a web-based program that uses profile methods only

It is a web-based program that uses a hybrid of the profile and pairwise energy methods

Question 9 of 10

Question 10 of 10

10. Unlike DNA, which is mainly double stranded, RNA is double stranded, although an RNA molecule can self-hybridize at certain regions to form partial double-stranded structures.

False

True

Question 10 of 10

« Prev - Bioinformatics Mock Test 3

» Next - Bioinformatics Mock Test 5