Bioinformatics Mock Test 5

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Question 1 of 10

1. In medical applications, the ultimate goal of gene mapping is to disease genes.

True

False

Question 1 of 10

Question 2 of 10

2. Fichant and Burks (1991) described a program, tRNAscan, that searches a genomic sequence with a sliding window searching simultaneously for matches to a set of invariant bases and conserved self-complementary regions in tRNAs with an accuracy of 97.5%.

False

True

Question 2 of 10

Question 3 of 10

3. Which of the following is incorrect about the prediction of RNA secondary structure?

Every base is first compared to every other base by a type of analysis very similar to the dot matrix analysis

A row of matches in the RNA matrix indicates a succession of complementary nucleotides that can potentially form a double-stranded region

A row of matches in the RNA matrix indicates a failure of complementary nucleotides that can potentially form a double-stranded region

The sequence is listed across the top and down the side of the page, and G/C, A/U, and G/U base pairs are scored

Question 3 of 10

Question 4 of 10

4. Like Mfold, RNAfold only examines the energy terms of the optimal alignment in a dot plot.

False

True

Question 4 of 10

Question 5 of 10

5. Which of the following is incorrect about ARACHNE?

It doesn’t involve heuristic approach

It accepts base calls with associated quality scores assigned by Phred as input

It is a free UNIX program

It is for the assembly of whole-genome shotgun reads

Question 5 of 10

Question 6 of 10

6. Three scores, Pnum (i), Hnum (i,j), and Ssum, have been derived to assist with a determination of the reliability of a secondary structure prediction for a particular base i or a base pair i,j. Which of the following is not a correct regarding Ssum?

is also called as ss-count

is the number of foldings in which base i is single-stranded multiplied by m, the number of folding

is the number of foldings in which base i is single-stranded divided by m, the number of folding

gives the probability that base i is single-stranded

Question 6 of 10

Question 7 of 10

7. The shotgun approach _______ sequences clones from _____ of cloned DNA.

specifically, both ends

randomly, one end

specifically, one end

randomly, both ends

Question 7 of 10

Question 8 of 10

8. The type of algorithm that _____ predefined alignment is ______ for reasonably conserved sequences.

requires, less successful

doesn’t require, more successful

doesn’t require, relatively successful

requires, relatively successful

Question 8 of 10

Question 9 of 10

9. If prediction accuracy can be represented using a ______ the ______ programs score roughly 20% to 60% depending on the length of the sequences.

multiple parameter, comparative–based

multiple parameter, ab initio–based

single parameter, ab initio–based

single parameter, comparative–based

Question 9 of 10

Question 10 of 10

10. One of the first methods used to find tRNA genes was to search for sequences that are complementary and can fold into a knot like the three found in tRNAs.

False

True

Question 10 of 10