Bioinformatics Mock Test 8

10%

Question 1 of 10

1. The promoter sequence may determine the expression of one gene or a number of linked genes downstream.

False

True

Question 1 of 10

Question 2 of 10

2. Operon prediction is less important in prokaryotic promoter prediction.

False

True

Question 2 of 10

Question 3 of 10

3. Shine-Delgarno sequence, which is a stretch of purine-rich sequence complementary to 16S rRNA in the ribosome.

True

False

Question 3 of 10

Question 4 of 10

4. An understanding of the importance of different factors in a particular interaction is important if confidence in the results is required. Which of the following are not those factors?

Shape

Hydrophobicity

Electrostatics

Question 4 of 10

Question 5 of 10

5. Once an operon structure is known ______ for the presence of a promoter and regulatory elements _____ in the operon do not possess such DNA elements.

only first two genes are predicted, whereas next few genes

only the first hundred genes are predicted, whereas next few genes

only the first gene is predicted, whereas other genes

only first ten genes are predicted, whereas next few genes

Question 5 of 10

Question 6 of 10

6. Oligomers are often obligate complexes meaning that the free-energy cost of dissociation is high and they exist as oligomers under physiological conditions.

False

True

Question 6 of 10

Question 7 of 10

7. Which of the following is untrue about Prediction Using Discriminant Analysis for Gene Prediction?

Some gene prediction algorithms rely on discriminant analysis, either LDA or quadratic discriminant analysis (QDA), to improve accuracy

QDA draws a curved line based on a quadratic function

LDA works by plotting a three-dimensional graph of coding signals versus all potential 3’ splice site positions

LDA works by drawing a diagonal line that best separates coding signals from noncoding signals based on knowledge learned from training data sets of known gene structures

Question 7 of 10

Question 8 of 10

8. TSSW is a web program that distinguishes promoter sequences from non-promoter sequences based on a combination of unique content information such as hexamer/trimer frequencies and signal information such the TATA box in the promoter region.

True

False

Question 8 of 10

Question 9 of 10

9. Information about shape, hydrophobicity, electrostatics, evolutionary relationships and conformational flexibility is not always available and the search for a universally applicable scoring function as well as an adequate treatment of conformational flexibility is ongoing.

True

False

Question 9 of 10

Question 10 of 10

10. In Ab Initio–Based Programs for Gene Prediction-- Gene content refers to coding statistics, which includes nonrandom nucleotide distribution, amino acid distribution, synonymous codon usage, and hexamer frequencies.

True

False

Question 10 of 10