Bioinformatics Mock Test 9

10%

Question 1 of 10

1. The Common Object Request Broker Architecture (CORBA) is the Object Management Group’s interface for objects.

True

False

Question 1 of 10

Question 2 of 10

2. In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.

True

False

Question 2 of 10

Question 3 of 10

3. For a protein search, which of the following is the wrong choice for fields?

Issue

Accession (number)

Journal number

E. C. number

Question 3 of 10

Question 4 of 10

4. Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.

True

False

Question 4 of 10

Question 5 of 10

5. Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.

not applicable to archea genomes

not applicable to eukaryote genomes

not applicable to prokaryote genomes

applicable to eukaryote genomes

Question 5 of 10

Question 6 of 10

6. The investigation (Aloy and Russel) of domain combinations in multidomain proteins by Bashton and Chothia focuses on two-domain proteins belonging to the Rossmann domain family.

False

True

Question 6 of 10

Question 7 of 10

7. Which of the following is incorrect about ENTREZ?

It provides a series of forms that can be filled out to retrieve a DNA or protein sequence

It provides a series of forms that can be filled out to retrieve a Medline reference related to the molecular biology sequence databases

It is a resource prepared only by the staff of the National Center for Biotechnology Information

One straightforward way to access the sequence databases is through ENTREZ

Question 7 of 10

Question 8 of 10

8. Which of the following is untrue about DNA sequencing methods?

New strands of DNA are synthesized from the end of the primer

Taq polymerase is quite heat sensitive

Purified fragments of DNA cut from plasmid/phage clones or amplified by polymerase chain reaction (PCR)

Clones of DNA fragments are denatured to single strands, and one of the strands is hybridized to an oligonucleotide primer

Question 8 of 10

Question 9 of 10

9. Which of the following is wrong about Genetics Computer Group Sequence Format?

Information about the sequence in the GenBank entry is not included but the line information is carried out

Lines of information are terminated by two periods, which mark the end of information and the start of the sequence on the next line

Earlier versions of the Genetics Computer Group (GCG) programs require a unique sequence format and include programs that convert other sequence formats into GCG format

If one or more sequence characters become changed through error, a program reading the sequence will be able to determine that the change has occurred because the checksum value in the sequence entry will no longer be correct

Question 9 of 10

Question 10 of 10

10. An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.

gene interactions, only three to four orthologs

gene interactions, two orthologs

protein interactions, two or more orthologs

protein interactions, two orthologs

Question 10 of 10

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