Bioinformatics Practice Test 10

1. Which of the given statement is incorrect about Clusters of functionally related genes?

The function of a particular gene can sometimes be predicted, given the known function of a neighboring, closely linked gene

In related organisms, gene order on the chromosome is least likely to be conserved

In microbial genomes, genes specifying a metabolic pathway may be contiguous on the genome where they are coregulated transcriptionally in an operon by a common promoter

As the relationship between the organisms decreases, local groups of genes remain clustered together, but chromosomal rearrangements move the clusters to other locations

2. The retroposons include short _________ interspersed nuclear elements (SINES).

100–3000 bp long

80–300 bp long

80–500 Mbp long

90–4000 bp long

3. Which of the given statement is incorrect?

An early classification scheme for eight related groups of E. coli genes included categories for enzymes, transport elements

An early classification scheme for eight related groups of E. coli genes included categories for regulators, membranes, structural elements, protein factors, leader peptides, and carriers

Ninety percent of E. coli genes related by significant sequence similarity fell into these same broad categories

Paralogous sequences, frequently are found to have dissimilar functions

4. In nondividing cells, a mixture of lightly and darkly stained chromosomal regions called euchromatin and heterochromatin respectively, are observed.

True

False

5. The human genome contains about _________ of class II of elements that probably predate human evolution (Smit 1996).

200,000 copies

20,00,000 copies

2,00,00,000 copies

2,000 copies

6. Which of the given statements is incorrect about Searching for orthologs to a protein family in an EST database?

ESTs with a high percent identity with the query sequence, a long alignment with the query sequence, and a very low E value of the alignment score represent groups of paralogous and orthologous genes

To identify orthologs as the most closely related sequence, ESTs were aligned using the amino acid alignment as a guide

Searches of EST databases for matches to a query sequence routinely produce minimal amounts of output that must be searched manually for significant hits

To identify orthologs as the most closely related sequence, a phylogenetic tree was produced by the maximum likelihood method

7. The all-against-all analyses provide an indication as to the number of protein/gene families in an organism. This number represents the core proteome of the organism from which all biological functions have diversified.

False

True

8. _______ of the Drosophila sequence is composed of TEs and _____ is heterochromatic regions that do not include genes.

one-sixth, one-third

one-fifth, one-fourth

one-sixth, one-eighth

one-fourth, one-third

9. WU-BLAST produces P scores and BLAST (NCBI) produces E scores where _________

E = ln (1 + P)

E = ln (1 - P)

E = ln (1 + P²)

E = ln (1 – P²)

10. Introns can remain at a corresponding position in a eukaryotic gene for long periods of evolutionary time.

True

False