Bioinformatics Practice Test 6

1. A supervised analysis refers to classification of data into a set of predefined categories. For example, depending on the purpose of the experiment, the data can be classified into predefined ‘diseased’ or ‘normal’ categories.

True

False

2. which of the following is incorrect about Oligonucleotide Design in A microarray?

The length of oligonucleotides is typically in the range of twenty-five to seventy bases long

DNA microarrays are generated by fixing oligonucleotides onto a solid support

The oligonucleotides don’t react with cDNA samples

The oligonucleotide array slide represents thousands of preselected genes from an organism

3. Which of the following is incorrect regarding Mascot and ProFound?

ProFound searches a protein sequence database using MS fingerprinting information

Mascot is a web server that identifies proteins based on peptide mass fingerprints, sequence entries, or raw MS/MS data from one or more peptides

Bayesian algorithm is not involved in ProFound

ProFound is a web server with a set of interconnected programs

4. Which of the following is incorrect regarding the terminologies of phylogenetics?

Lineage is often synonymous with a tree branch leading to a defined monophyletic group

A group of taxa descended from a single common ancestor is defined as a clade or monophyletic group

In a monophyletic group, two taxa share a unique common ancestor shared by other taxa as well

When a number of taxa share more than one closest common ancestors, they do not fit the definition of a clade. In this case, they are referred to as paraphyletic

5. Chloroplast localization signals are also located in the __________ terminus and are about 25 to 100 residues in length, containing very few _______ charged residues but many hydroxylated residues such as serine.

N, positively

C, negatively

C, positively

N, negatively

6. The genome annotation process involves two steps: gene prediction and functional assignment.

True

False

7. To use molecular data to reconstruct evolutionary history requires making a number of reasonable assumptions. Which of the following is incorrect about it?

Parent branch splits into two daughter branches at any given point

The molecular sequences used in phylogenetic construction share a common origin

Phylogenetic divergence cannot be bifurcating

The molecular sequences used in phylogenetic construction are homologous

8. Which of the following is incorrect regarding gene annotation?

Gene structures are first predicted by ab initio exon prediction programs

The predicted genes are compared with experimentally determined cDNA and EST sequences

The gene annotation of the human genome employs a combination of theoretical prediction and experimental verification

The pairwise alignment programs are not involved

9. Which of the following is incorrect about Classification of microarray data?

For microarray data, clustering analysis identifies coexpressed but not coregulated genes

Genes within a category have more similarity in expression than genes from different categories.

For microarray data, clustering analysis identifies and coregulated but not coexpressed genes

For microarray data, clustering analysis identifies coexpressed and coregulated genes

10. The descriptions of morphological traits are often _____ which are due to _____

ambiguous, multiple genetic factors

lucid, more than one genetic factors

clear, multiple genetic factors

ambiguous, one or two genetic factors