Drug and Pharmaceutical Biotechnology Practice Test 2

1. Which one of the following sentences depicts the function of Disintegrants correctly?

These agents help in holding the powders together to form granules

Added when the required dosage is inadequate

These agents help in the flow of granules and reduce friction between particles

These agents overcome the cohesive strength of the tablets and help in dissolution

2. Which drugs cannot pass the Capillary endothelial Barrier?

Drugs bound to a chemical moiety

Drugs bound to blood components

All drugs can pass

Molecular size less than 600 Dalton

3. Which one of the following sentences will be the actual definition of distribution?

Transfer of drug from the administration dosage to surrounding fluid

Transfer of the drug from the oral cavity to the intestine

Reversible transfer of drug between blood and extravascular fluids and tissues

Transfer of drug from the surrounding the fluid to the blood

4. A large amount of binders tends to increase the hardness of tablets.

True

False

5. Acidic drugs like imipramine, lidocaine bind to alpha 1 Acid Glycoprotein.

False

True

6. Who has more intracellular and extracellular water more in their body?

Adults Of age more than 20

Aged

Children at puberty

Infants

7. What is the function of the blood-testis barrier?

Restricts the passage of drug to sperms

Restricts the passage of drugs to spermatocytes

Restricts the passage of drug to the testis

Restricts the passage of drugs to spermatocytes and spermatids

8. The liver is the major site of drug metabolism.

False

True

9. Which one of these is not an approach to make the drug cross the blood-brain barrier?

Use of highly lipophilic drug only

Use of drug carriers to cross the BBB

Osmotic disruption of the blood-brain barrier

Using permeation enhancers

10. From the surface of villi protrude smaller projection known as __________

Fingers

Microvilli

Cilia

Villus